On a rural island off the coast of Nicaragua, the landscape seems picturesque at first, with children bicycling along dirt roads that encircle vast fields of sugarcane. Until you start to notice how few men there are on the Nicaraguan island, you might not guess that "La Isla de las Viudas" is one of the many areas in Central America whose population has been devastated over the past two decades by a mysterious kidney disease. This regional epidemic lies at the intersection of a social injustice and a public health crisis, where “Chronic Kidney Disease of Unknown origin” (CKDu) has become more deadly than HIV/AIDS, diabetes, and leukemia combined.